The Northcott Lab in the Department of Developmental Neurobiology at St. Jude Children's Research Hospital is seeking a highly skilled Scientist or Lead Researcher to perform developmental and tumorigenic studies related to childhood brain cancer using organoids, patient-derived xenografts (PDX), and tumoroids. The Northcott lab is internationally recognized for making seminal contributions to the understanding of the genomics and developmental biology of childhood brain tumors.

We seek a technically skilled, self-motivated, and meticulously organized stem cell scientist with expertise in primary cell culture, including embryonic stem cells (ESCs) and/or induced pluripotent stem cells (iPSCs). Experience with organoid differentiation protocols, propagating PDX models, and/or tumoroids is considered highly desirable. Candidates should be able to perform and coordinate a wide range of laboratory research procedures and conduct complex support tasks and projects determined by our current research. Duties will include propagation of ESCs and iPSCs, generation, maintenance, and characterization of organoids, PDX, and tumoroids for the purpose of studying oncogenic mechanisms underlying childhood brain tumors.

Prior experience with molecular and cellular assays such as single-cell/nuclei sequencing, ATAC-seq, ChIP-seq, CUT&RUN, immunofluorescence imaging, and FACS analysis are highly desirable. The position will involve interaction with other laboratory staff and trainees on multidisciplinary projects and presentation of scientific findings during regular working group meetings. Candidates should be able to communicate effectively and work both independently and as part of a team.

Job Responsibilities:

• Performs laboratory experiments using existing, modified or newly developed techniques/protocols

• Sets up protocols, trouble shoots experiments using new or modified laboratory techniques

• Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data and reports results

• May assist in the drafting and editing of manuscripts.

• Provides basic lab operation support to include equipment maintenance and purchasing. Monitors inventory and orders lab supplies as needed. Performs calibration of instruments and equipment as necessary.

• Provides guidance to entry-level employees.

• Performs other related duties as assigned in order to meet the goals of the department and institution

• Maintains regular and predictable attendance

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required

Lead Researcher Minimum Experience:

• Five (5) years of relevant, post-degree work experience is required

• Two (2) years of relevant post-degree work experience is required with a Master's degree

• No experience is required with a PHD

Scientist Minimum Experience:

• Seven (7) years of relevant post-degree work experience is required

• Five (5) years of relevant post-degree work experience is required with a Master's degree

• Three (3) years of relevant post-degree work experience is required with a PhD

Compensation

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Diversity, Equity and Inclusion

St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

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